Early predictors of postnatal developmental disorders in prematurely born children
https://doi.org/10.37489/2949-1924-0099
EDN: VIABWB
Abstract
Relevance. Deviations in somatometric indicators in infancy lay the foundation for the development of chronic diseases in the future. The search for early prognostic indicators of physical development disorders in premature infants creates the prerequisites for their timely correction.
Objective. To determine the significance of changes in blood levels of IGF-1 in the neonatal period for predicting the physical development of premature infants.
Materials and methods. A prospective controlled study of 73 premature infants was conducted. Physical development indicators at 6 and 12 months of age were analyzed in two groups of children with different dynamics of insulin-like growth factor-1 (IGF-1) levels in the blood during the neonatal period.
Results. At 6 and 12 months of age, deviations in height or body weight from reference values were more common in children who had relatively low hormone levels in the early neonatal period, followed by an increase.
Conclusions. The dynamics of somatometric parameters in infants with increasing IGF-1 levels in the blood during the neonatal period indicate the possibility of using this biochemical indicator for early prediction of physical development deviations in premature infants.
Supporting agencies: The work was carried out without sponsorship
About the Authors
K. V. Dashichev
Yaroslavl State Medical University
Russian Federation
Competing Interests:
Russian Federation
Kirill V. Dashichev, Cand. Sci. (Med.), Associate Professor
Department of Pediatrics № 2
Yaroslavl
Competing Interests:
Authors declare no conflict of interest requiring disclosure in this article
E. P. Sitnikova
Yaroslavl State Medical University
Russian Federation
Competing Interests:
Russian Federation
Elena P. Sitnikova, Dr. Sci. (Med.), Professor, Head of the Department
Department of Pediatrics № 2
Yaroslavl
Competing Interests:
Authors declare no conflict of interest requiring disclosure in this article
N. V. Olandar
Yaroslavl State Medical University
Russian Federation
Competing Interests:
Russian Federation
Nataliya V. Olandar, Cand. Sci. (Med.), Associate Professor
Department of Pediatrics № 2
Yaroslavl
Competing Interests:
Authors declare no conflict of interest requiring disclosure in this article
T. V. Vinogradova
Yaroslavl State Medical University
Russian Federation
Competing Interests:
Russian Federation
Tatiana V. Vinogradova, Assistant lecturer
Department of Pediatrics № 2
Yaroslavl
Competing Interests:
Authors declare no conflict of interest requiring disclosure in this article
A. S. Shitova
Yaroslavl State Medical University
Russian Federation
Competing Interests:
Russian Federation
Anna S. Shitova, Assistant lecturer
Department of Pediatrics № 2
Yaroslavl
Competing Interests:
Authors declare no conflict of interest requiring disclosure in this article
References
1. Belousova TV, Andrushina IV. Intrauterine growth retardation and its impact on children's health in later life. the possibility of nutritional support. Voprosy` sovremennoj pediatrii=Current Pediatric. 2015;14(1):23-30. (In Russ.). DOI: 10.15690/vsp.v14i1.1259
2. Stettler N, Iotova V. Early growth patterns and long-term obesity risk. Curr Opin Clin Nutr Metab Care. 2010;13(3):294-9. doi: 10.1097/MCO.0b013e328337d7b9
3. Netrebenko OK, Scheplyagina LA. Nutrition in the early stages of life. Causes of violations and consequences. Nestle Nutrition Institute, 2015. (In Russ.)
4. Razin VA, Nizamova LT, Gnoevykh VV et al. Insulin-like growth factor 1: cardiovascular morbidity prognosis. Ul'yanovskiy mediko-biologicheskiy zhurnal = Ulyanovsk Medico-biological Journal. 2021;4:6–17 (In Russ.) DOI: 10.34014/2227-1848-2021-4-6-17.
5. Jensen-Cody SO, Potthoff MJ. Hepatokines and metabolism: Deciphering communication from the liver. Mol Metab. 2021 Feb;44:101138. doi: 10.1016/j.molmet.2020.101138.
6. Hellstrom A, Ley D, Hansen-Pupp I, et al. Insulin-like growth factor 1 has multisystem effects on fetal and preterm infant development. Acta Pædiatrica. 2016;105(6):576-86. DOI: 10.1111/apa.13350
7. Shabalov N.P. Neonatology, vol. 1. M.: GEOTAR-Media, 2020 (In Russ.)
8. Yakovenko DV, Sazonova EN, Simankova AA et al. The effect of dihydroquercetin on proliferative and anabolic processes in various cell populations of newborn white rats subjected to antenatal hypoxia. E`ksperimental`naya i klinicheskaya farmakologiya = Experimental and Clinical Pharmacology. 2019; 82(4):41-44. (In Russ.) doi: 10.30906/0869-2092-2019-82-4-41-44.
9. Custodio RJ, do Carmo Custodio VI, Scrideli CA, Sader Milani SL, Cervi MC, Cupo P, Martinelli CE Jr. Impact of hypoxia on IGF-I, IGF-II, IGFBP-3, ALS and IGFBP-1 regulation and on IGF1R gene expression in children. Growth Horm IGF Res. 2012 Oct;22(5):186-91. doi: 10.1016/j.ghir.2012.07.001.
10. Netrebenko OK, Ukraintsev SE, Melnikova IY. Obesity in Children: New Prevention Concepts and Approaches. Literature Review. Voprosy` sovremennoi pediatrii = Current Pediatrics. 2017; 16 (5): 399–405. (In Russ.) doi: 10.15690/vsp.v16i5.1804
11. Calcaterra V, Verduci E, Magenes VC et al. The Role of Pediatric Nutrition as a Modifiable Risk Factor for Precocious Puberty. Life. 2021; 11(12):1353. DOI: 10.3390/life11121353.
Review
For citations:
Dashichev K.V., Sitnikova E.P., Olandar N.V., Vinogradova T.V., Shitova A.S. Early predictors of postnatal developmental disorders in prematurely born children. Patient-Oriented Medicine and Pharmacy. 2025;3(3):28-33. (In Russ.) https://doi.org/10.37489/2949-1924-0099. EDN: VIABWB
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