MD, PhD, professor, Academician of Russian Academy of Sciences, Head of department of clinical pharmacology and therapy, Rector of the Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow; President of the Russian Society of Pharmacogenetics, Pharmacokinetics and Personalized Therapy

ACADEMIC DEGREE:

Doctor of Medical Sciences (2007) in the specialty "Pharmacology, Clinical Pharmacology" - 14.03.06

ACADEMIC RANK:

• Professor (2013)
• Professor of the Russian Academy of Sciences (December 2015)
• Corresponding Member of the Russian Academy of Sciences (since October 28, 2016)
• Academician of the Russian Academy of Sciences (since June 2, 2022)

JOB TITLE:

• Head of the Department of Clinical Pharmacology and Therapy, Russian Medical Academy of Continuing Professional Education, Ministry of Health of the Russian Federation, Moscow
• Rector of the Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow

SPECIALITY:

• clinical pharmacologist
• therapist

PLACE OF WORK:

• Department of Clinical Pharmacology and Therapy, Russian Medical Academy of Continuing Professional Education of the Ministry of Health of the Russian Federation, Moscow, Head of Department, Rector

EDUCATION:

Graduated with honors from the medical faculty of the First Moscow Medical Institute Sechenov Ministry of Health of the USSR, now the First Moscow State Medical University Sechenov. Since 1999, he has studied in clinical residency in the specialty "therapy," and since 2001 in full-time postgraduate studies at the MMA named after. Sechenov, which he completed ahead of schedule in 2002, having defended his Ph.D. thesis “The use of stress echocardiography with dobutamine to predict the pharmacodynamic effects of the cardioselective beta-blocker metoprolol in patients with chronic heart failure” (supervisor – academician of the Russian Academy of Sciences Kukes V.G.).

AREA OF SCIENTIFIC INTERESTS:

• clinical pharmacogenetics and pharmacogenomics
• applied aspects of clinical and pharmacological technologies of personalized medicine (pharmacogenetic testing, therapeutic drug monitoring) in diseases of the internal organs
• clinical aspects of the study of drug biotransformation, including the study of cytochrome P-450 isoenzymes, drug transporters (P-glycoprotein, organic anion, and cation transporters)
• molecular mechanisms of pharmacokinetic drug-drug interactions and polypharmacy in clinical practice
• issues of preventing adverse reactions and ensuring the drug safety of patients
• fight against polypharmacy and deprescribing in elderly and senile patients
• information technologies in clinical pharmacology
• methodology to teaching clinical pharmacology

ADDITIONAL ABOUT MYRSELF:

Since 2002, he worked as an assistant, and since 2004 as an associate professor in the Department of Clinical Pharmacology and Propaedeutics of Internal Diseases of the Moscow Medical Academy named after Sechenov. In 2006, he defended his doctoral dissertation “The importance of pharmacogenetic studies of the biotransformation system and transporters for optimizing the pharmacotherapy of cardiovascular drugs” (scientific consultant – academician of the Russian Academy of Sciences Kukes V.G.). From 2007 to the present, he has been working as a professor in the same department at the First Moscow State Medical University Sechenov.

Additionally, from 2007 to 2010 worked as a chief researcher at the Institute of Clinical Pharmacology of the Federal State Budgetary Institution "Scientific Center for Expertise of Medicinal Products" at the Ministry of Health and Social Development, and from 2010 to 2013 - Head of the Department of Personalized Medicine and Clinical Pharmacogenetics at the Center for Clinical Pharmacology of the Department of Science and Innovation of the Federal State Budgetary Institution "NCESMP" of the Ministry of Health. Since 2012 - Professor of the Department of Clinical Pharmacology and Therapy of the RMANPO, since 2013 - Head of the Department and since 2019 - Rector (elected in November 2018, appointed in April 2019).

Scientific research Sychev D.A. in the field of pharmacogenetics and are well known and recognized abroad. According to the RSCI, he published more than 750 publications, including in foreign journals. Hirsch index (RSCI) - 25, Hirsch index (Scopus) - 7 (as of April 2020).

Sychev D.A. is a co-author of 8 teaching aids, 2 textbooks, 2 curricula, co-author of the National Guidelines for Clinical Pharmacology (he was also one of its scientific editors) and the National Guidelines for Medical Genetics, author of 2 scientific monographs: "Clinical Pharmacogenetics" (2007), "Metabolism of drugs: the scientific basis of personalized medicine" (2008), Workshop for medical students "General issues of clinical pharmacology" (2010), guidelines for pharmaceutical companies "Recommendations for the study of biotransformation and transporters of new drugs : study design, data analysis and entering information into instructions for use" (edited by Academician of the Russian Academy of Sciences Kukesa V.G.) and methodological recommendations for practicing physicians" Personalized anticoagulant therapy based on the results of pharmacogenetic testing", textbook "Polypharmacy in clinical practice » (2016, 2018) , scientific editor of the textbook "Protocols for ensuring the safety of medical activities in a multidisciplinary hospital" (2020).

Sychev D.A. is the founder of the national scientific school in pharmacogenetics and pharmacogenomics. Under his leadership, 26 candidates and two doctoral dissertations were prepared and defended.

SOCIAL ACTIVITY:

Sychev D.A. From 2005 to 2009, he was the Scientific Secretary of the Problematic Educational and Methodological Commission for Teaching Clinical Pharmacology of the Ministry of Health and Social Development, he is the Consul from Russia (national coordinator) in the European Association of Clinical Pharmacologists and Pharmacotherapists (EACPT, from 2006 to 2015) and a member of the Executive Committee of the same association (from 2011 to 2015), a member of the Presidium of the Russian branch of the European Association for Preventive, Predictive and Personalized Medicine (EPMA, from 2011 to 2013), a member of the Interregional Society for Pharmacoeconomic Research (IRSPRO, since 2005 to the present), member of the Board of the Moscow City Scientific Society of Therapists (MGNOT, from 2015 to the present), member of the Formulary Committee of the Russian Academy of Medical Sciences (from 2009 to 2013), coordinator of the Formulary Committee of the National Medical Chamber (from 2016 to the present time), president of the Society for Pharmacogenetics, Pharmacokinetics, and Personalized Therapy (OFFPT, pharmacogenetica.rf), Deputy Chairman of the Profile Commission on Clinical Pharmacology under the Ministry of Health of Russia (since 2019), member of the Dissertation Council for the defense of candidate and doctoral dissertations at the First Moscow State Medical University named after I.M. Sechenov (specialty 14.03.06 Pharmacology, clinical pharmacology).

Sychev D.A. is a member of the editorial board of the following scientific publications:

• editor-in-chief of the journal "Pharmacogenetics and pharmacogenomics" (from 2015 to the present),
• member of the editorial boards of the following journals: "Good Clinical Practice", "Pharmacokinetics and Pharmacodynamics", "Antibiotics and Chemotherapy", "Real-World Data & Evidence", "Creative Cardiology, Biomedicine, Molecular Medicine, Pharmacy Kazakhstan,” “Healthcare of the Far East,” “Pedagogy of professional medical education,” “Bulletin of the Scientific Center for Expertise of Medical Applications,” “Russian Biomedical Bulletin named after Academician I.P. Pavlova", "Pediatrics. Consilium Medicum," "Clinical Microbiology and Antimicrobial Chemotherapy," "Russian Journal of Geriatric Medicine," "Clinical Pharmacology and Therapy," "Bulletin of the Russian Academy of Medical Sciences," "Modern Rheumatology"
• was the executive secretary of the journal "Drugs: Applied Pharmacology and Personalized Pharmacotherapy" (from 2009 to 2011).

Sychev D.A. was a member of the Expert Council on Therapeutic Sciences of the Higher Attestation Commission of Russia (from 2014 to 2019), an expert of the Russian Foundation for Basic Research (RFBR) and the Russian Science Foundation (RSF).

From 2016 to the present Sychev D.A. is the President of the Society of Pharmacogenetics, Pharmacokinetics and Personalized Therapy (SPPT), whose main area of activity is the development and implementation of omics technologies for personalized therapy into clinical practice. The printed organ of the OFFPT is the journal "Pharmacogenetics and pharmacogenomics."

AWARDS:

• Prize from the Government of the Russian Federation in the field of science and technology (2007)
• Prize from the Russian Academy of Sciences. N.P. Kravkov for the best work in pharmacology and toxicology (2008)
• Commendation from the Ministry of Health of Russia (2018)
• Diploma from the Russian Academy of Sciences (2020)