Pain treatment individualization in patients with advanced cancer using immediate release morphine
https://doi.org/10.37489/2949-1924-0050
EDN: LLKJAC
Abstract
Adequate pain relief through individual tailoring of the basic analgesic in suited dose and drug formulation, as well as the use of adjuvant and supportive therapy, relieves the suffering of patients with advanced cancer in most cases. Noninvasive opioids in immediate and modified release formulations play a key role in treating severe chronic pain syndrome. We present a series of case studies to illustrate morphine tablet and oral solution administration as part of an individual pain therapy regimen, such as opioid dose titration, treatment of breakthrough pain, and around-the-clock pain control.
About the Authors
O. V. Osetrova
Samara hospice
Russian Federation
Competing Interests:
Russian Federation
Olga V. Osetrova — chief physician of the Samara Hospice, chief freelance specialist in palliative care of the Volga Federal District, board member of the Association of Professional Participants in Hospice Care
Samara
Competing Interests:
The authors declare no conflict of interest
A. V. Sidorov
Yaroslavl State Medical University; First Moscow State Medical University named after I.M. S echenov
Russian Federation
Competing Interests:
Russian Federation
Alexander V. Sidorov — Doctor of Medicine Sciences, Head Department of Pharmacognosy and Pharmaceutical Technology; Chief Researcher
Yaroslavl
Moscow
Competing Interests:
The authors declare no conflict of interest
D. V. Nevzorova
Yaroslavl State Medical University
Russian Federation
Competing Interests:
Russian Federation
Diana V. Nevzorova — Ph. D., chief freelance specialist in palliative care of the Ministry of Health of Russia, director of the Federal Scientific and Practical Center for Palliative Medical Care
Yaroslavl
Competing Interests:
The authors declare no conflict of interest
References
1. Clinical guidelines "Chronic pain syndrome (CPS) in adult patients in need of palliative care" (approved by the Ministry of Health of the Russian Federation, 2023).
2. Olarte JM. Breakthrough cancer pain and rational drug use. Support Care Cancer. 2017 Apr;25 (Suppl 1):11-17. doi: 10.1007/s00520-017-3636-5.
3. Fallon M, Giusti R, Aielli F, Hoskin P, Rolke R, Sharma M, Ripamonti CI; ESMO Guidelines Committee. Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines. Ann Oncol. 2018 Oct 1;29(Suppl 4):iv166-iv191. doi: 10.1093/annonc/mdy152.
4. Smith HS. Rapid onset opioids in palliative medicine. Ann Palliat Med. 2012 Apr;1(1):45-52. doi: 10.3978/j.issn.2224-5820.2012.01.01.
5. Zucco F, Bonezzi C, Fornasari D. Breakthrough cancer pain (BTcP): a synthesis of taxonomy, pathogenesis, therapy, and good clinical practice in adult patients in Italy. Adv Ther. 2014 Jul;31(7):657-82. doi: 10.1007/s12325-014-0130-z.
6. Adult Cancer Pain. National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology. Version 2.2024.
7. Osetrova O.V., Nevzorova D.V., Sidorov A.V. Experience and features of the use of non-invasive morphine preparations with immediate-release (short-acting) in the practice of the Samara Hospice ANO. Pallium: palliative and hospice care. 2024; 1(22): 5-8.
Review
For citations:
Osetrova O.V., Sidorov A.V., Nevzorova D.V. Pain treatment individualization in patients with advanced cancer using immediate release morphine. Patient-Oriented Medicine and Pharmacy. 2024;2(2):51-57. (In Russ.) https://doi.org/10.37489/2949-1924-0050. EDN: LLKJAC
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