Review of the monograph by Yarovoy S.K., Khokhlov A.L. “Practical issues of rational antibacterial therapy”

In November 2023, the monograph “Practical issues of rational antibacterial therapy” under. general ed. Yarovoy SK, Khokhlov AL was published. This monograph is devoted to practical issues of empirical therapy for the most common nonspecific infectious and inflammatory diseases. Chapter 1 presents the main provisions of antimicrobial therapy from the perspective of clinical pharmacology. The general patterns of prescription and distribution of antibacterial agents, the concepts of basic and reserve drugs, selection of hospital strains, natural and acquired resistance are explained. Chapter 2 is devoted to a comparison of antibacterial drugs in pairs with each other based on an analysis of their spectra of antimicrobial activity presented in the instructions for use, as well as well-known information about their toxicity and the comparative frequency of dysbiosis. Pairs of drugs for comparison were selected based on actual clinical practice. Chapter 3 discusses combination (multicomponent) antibacterial therapy. Appropriate and possible combinations of two antimicrobial agents have been identified. Recommendations for three-component antibacterial therapy are presented separately. Chapter 4 is entirely devoted to undesirable antimicrobial regimens. Options with insufficient effectiveness, an unsatisfactory safety profile, and those that do not meet epidemiological requirements were analyzed. Chapter 5 is a detailed answer to a purely applied question about replacing a promicrobial agent in three formalized situations: “ineffective”, “unsafe”, “absent”.

The book is intended for clinical pharmacologists, therapists, surgeons and other specialists, students of advanced training courses, and senior students of medical universities.