Preview

Patient-Oriented Medicine and Pharmacy

Advanced search

Chronic neuroborreliosis and post-COVID syndrome: a clinical case

https://doi.org/10.37489/2949-1924-0057

EDN: FOSOJL

Abstract

Lyme borreliosis is a natural focal, vector-borne disease caused by Borrelia burgdorferi sensu lato. The transmission of ixodes ticks is characterized by a staged course with damage to various organs and systems. This disease is an urgent problem in medicine because of the peculiarities of its clinical course, including in the late period. Not infrequently, due to the lack of vigilance of physicians and the polymorphism of the clinical presentation of the disease, Lyme borreliosis runs under the masks of other diagnoses. In Covid-19, caused by the new coronavirus SARS-CoV-2, both in the acute period of the disease and later develop systemic clinical manifestations in the central and peripheral nervous systems and the musculoskeletal system. These features are particularly characteristic of the post-Covid-19 syndrome.

A clinical case of chronic neuroborreliosis and post-COVID-19 syndrome with lesions in the nervous and muscular systems is presented.

About the Authors

N. S. Baranova
Yaroslavl state medical university
Russian Federation

Natalya S. Baranova — Dr. Sci. (Med.), Professor of the Department of Nervous Diseases with Medical Genetics and Neurosurgery

Yaroslavl


Competing Interests:

The authors declare no conflict of interest.



Y. S. Ostapenko
Yaroslavl state medical university
Russian Federation

Yaroslav S. Ostapenko — Postgraduate student of the Department of Nervous Diseases with Medical Genetics and Neurosurgery

Yaroslavl


Competing Interests:

The authors declare no conflict of interest.



J. A. Malysheva
Russian Railways-Medicine Clinical Hospital
Russian Federation

Julia A. Malysheva — Rheumatologist

Yaroslavl


Competing Interests:

The authors declare no conflict of interest.



E. A. Malygina
Regional clinical hospital
Russian Federation

Elena A. Malygina — Rheumatologist, Head of  Rheumatology Department

Yaroslav


Competing Interests:

The authors declare no conflict of interest.



D. A. Kachura
Regional clinical hospital
Russian Federation

Dmitry A. Kachura — Cand. Sci. (Med.), Neurologist,  Head of the neurology department

Yaroslavl


Competing Interests:

The authors declare no conflict of interest.



S. S. Zolotavkina
Yaroslavl state medical university
Russian Federation

Svetlana S. Zolotavkina — Laboratory Technician of the Department of Polyclinic Therapy, Clinical Laboratory Diagnostics and Medical Biochemistry

Yaroslavl


Competing Interests:

The authors declare no conflict of interest.



A. A. Baranov
Yaroslavl state medical university
Russian Federation

Andrey A. Baranov — Dr. Sci. (Med.), professor, Head of the Department of the Department of Polyclinic Therapy, Clinical Laboratory Diagnostics and Medical  Biochemistry

Yaroslavl


Competing Interests:

The authors declare no conflict of interest.



References

1. Koedel U, Pfister HW. Lyme neuroborreliosis. Curr Opin Infect Dis. 2017;30(1):101-107. doi: 10.1097/QCO.0000000000000332.

2. Halperin JJ. A neurologist's view of Lyme Disease and other tick-borne infections. Semin Neurol. 2019;39(4):440-447. doi: 10.1055/s-0039-1692143/

3. Баранова Н.С., Спирин Н.Н., Овсянникова Л.А. и др. Поражение нервной системы при Лаймборрелиозе. Терапия. 2021; 5:51-59. [Baranova NS, Spirin NN, Ovsyannikova LA, et al. Nervous system damage in Lyme borreliosis. Therapy. 2021; 5:51-59. (In Russ.)] doi:10.18565/therapy.2021.5.51-59.

4. Dessau RB, van Dam AP, Fingerle V, et al. To test or not to test? Laboratory support for the diagnosis of Lyme borreliosis: a position paper of ESGBOR, the ESCMID study group for Lyme borreliosis. Clin Microbiol Infect. 2018; 24(2):118-124. doi: 10.1016/j.cmi.2017.08.025.

5. Гусев Е.И., Мартынов М.Ю., Бойко А.Н. и др. Новая коронавирусная инфекция (COVID-19) и поражение нервной системы: механизмы неврологических расстройств, клинические проявления, организация неврологической помощи. Журнал неврологии и психиатрии им. С.С. Корсакова. 2020;120(6):7–16. [Gusev E.I., Martynov M.Yu., Boyko A.N., et al. Novel coronavirus infection (COVID—19) and nervous system involvement: pathogenesis, clinical manifestations, organization of neurological care. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2020;120(6):7–16. (In Russ.)] doi: 10.17116/jnevro20201200617.

6. Насонов Е.Л. Коронавирусная болезнь 2019 (COVID-19): Размышления ревматолога. Научно-практическая ревматология. 2020;58(2):123- 132. [Nasonov E.L. Coronavirus disease 2019 (COVID-19): a rheumatologist’s thoughts. NauchnoPrakticheskaya Revmatologiya = Rheumatology Science and Practice. 2020; 58(2):123-132 (In Russ.)] doi: 10.14412/1995-4484-2020-123-132.

7. Насонов ЕЛ. Коронавирусная болезнь 2019 (COVID-19) и аутоиммунитет. Научно-практическая ревматология. 2021;59(1):5–30. [Nasonov E.L. Coronavirus disease 2019 (COVID-19) and autoimmunity. Nauchno-prakticheskaya revmatologiya = Rheumatology Science and Practice. 2021; 59(1):5–30 (In Russ.)] doi: 10.47360/1995-4484-2021-5-30.

8. ВОЗ, 2021 г.; https://www.who.int/publications/i/item/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1.

9. Каратеев А.Е., Амирджанова В.Н., Насонов Е.Л. и др. «Постковидный синдром»: в центре внимания скелетно-мышечная боль. Научно-практическая ревматология. 2021;59(3):255–262. [Karateev A.E., Amirdzhanova V.N., Nasonov E.L. et al. “Post-COVID syndrome”: The focus is on musculoskeletal pain. Nauchcno-Prakticheskaya Revmatologia = Rheumatology Science and Practice. 2021;59(3):255–262 (In Russ.)] doi: 10.47360/1995-4484-2021-255-262.

10. Екушева Е.В., Мартынов А.И., Горелов А.В. и др. Неврологические аспекты Long-COVID-инфекции. Методические рекомендации «Особенности течения Long-COVID-инфекции. Терапевтические и реабилитационные мероприятия». Терапия. 2022; 1 (Приложение):1-147. Ekusheva E.V., Martynov A.I., Gorelov A.V. et al. Neurological aspects of Long-COVID-infection. Methodical recommendations "Features of the course of Long-COVID-infection. Therapeutic and rehabilitation measures". Therapy. 2022; 1 (Supplement):1-147. (In Russ.)] doi: 10.18565/therapy.2022.1suppl.1-147.

11. Мазуров В.И., Беляева И.Б., Мартынов А.И. и др. Ревматологические аспекты Long-COVID-инфекции. Методические рекомендации «Особенности течения Long-COVID-инфекции. Терапевтические и реабилитационные мероприятия». Терапия. 2022; 1 (Приложение):1-147. [Mazurov V.I., Belyaeva I.B., Martynov A.I. et al. Rheumatologic aspects of Long-COVID-infection. Methodical recommendations "Features of the course of Long-COVID-infection. Therapeutic and rehabilitation measures". Therapy. 2022; 1 (Supplement):1-147. (In Russ.)] doi: 10.18565/therapy.2022.1suppl.1-147.

12. Насонов Е.Л. Пандемия коронавирусной болезни 2019 (COVID-19) и аутоиммунные ревматические заболевания: итоги и перспективы. Научно-практическая ревматология. 2024;62(1):32– 54. [Nasonov E.L. Coronavirus disease 2019 (COVID-19) pandemic and autoimmune rheumatic diseases: Outcomes and prospects. Nauchno-Prakticheskaya Revmatologia = Rheumatology Science and Practice. 2024;62(1):32–54 (In Russ.)] doi: 10.47360/1995-4484-2024-32-54.

13. Szewczyk-Dąbrowska A, Budziar W, Harhala M, et al. Correlation between COVID-19 severity and previous exposure of patients to Borrelia spp. Sci Rep. 2022;12(1):15944. doi: 10.1038/s41598-022-20202-x.

14. Леонова Г.Н., Шутикова А.Л., Попов А.Ф., Щелканов М.Ю. Верификация случая микст инфекции болезни Лайма, клещевого энцефалита и COVID-19. Acta biomedica scientifica. 2022; 7 (5-2): 67-73. [Leonova G.N., Shutikova A.L., Popov A.F., Shchelkanov M.Yu. Verification of a case of mixed infection with Lyme disease, tick-borne encephalitis and COVID-19. Acta biomedica scientifica. 2022; 7(5-2): 67-73 (In Russ.)] doi: 10.29413/ABS.2022-7.5-2.7.

15. Аронова Е.С., Белов Б.С., Гриднева Г.И. Постковидный синдром: клиническая картина, диагностика и лечение с позиции ревматолога. Современная ревматология. 2023;17(6):7–13. [Aronova E.S., Belov B.S., Gridneva G.I. Post-Covid syndrome: clinical picture, diagnosis and treatment from a rheumatologist perspective. Sovremennaya Revmatologiya=Modern Rheumatology Journal. 2023;17(6):7–13 (In Russ.)] doi: 10.14412/1996-7012-2023-6-7-13.

16. Oronsky B, Larson C, Hammond TC, et al. A review of persistent post-COVID syndrome (PPCS). Clin Rev Allergy Immunol. 2021; 20: 1–9. doi: 10.1007/s12016-021-08848-3.

17. Ely EW, Brown LM, Fineberg HV. National Academies of Sciences, Engineering, and Medicine Committee on Examining the Working Definition for Long Covid. Long Covid defined. N Engl J Med. 2024; Jul 31. doi: 10.1056/NEJMsb2408466. Epub ahead of print.

18. Chang R, Yen-Ting Chen T, Wang SI, et al. Risk of autoimmune diseases in patients with COVID-19: Aretrospective cohort study. EClinicalMedicine. 2023; 56:101783. doi: 10.1016/j.eclinm.2022.101783.

19. Bohan A, Peter J. Polymyositis and dermatomyositis (first of two parts). N. Engl. J. Med. 1975; 292:344– 347. doi: 10.1056/NEJM197502132920706.

20. Ghirardello A, Bassi N, Palma L, et al. Autoantibodies in polymyositis and dermatomyositis. Curr. Rheumatol. Rep. 2013;15:335. doi: 10.1007/s11926–013-0335–1.

21. Wang EY, Mao T, Klein J, et al. Diverse functional autoantibodies in patients with COVID-19. Nature. 2021;595(7866):283-288. doi: 10.1038/s41586-021-03631-y.

22. Hileman CO, Malakooti SK, Patil N, et al. New-onset autoimmune disease after COVID-19. Front Immunol. 2024;15:1337406. doi: 10.3389/fimmu.2024.1337406.

23. Grąźlewska W, Holec-Gąsior L. Antibody cross-reactivity in serodiagnosis of Lyme Disease. Antibodies (Basel). 2023;12(4):63. doi: 10.3390/antib12040063.

24. Dessau RB, Fryland L, Wilhelmsson P, et al. Study of a cohort of 1,886 persons to determine changes in antibody reactivity to Borrelia burgdorferi 3 months after a tick bite. Clin Vaccine Immunol. 2015; 22(7):823-7. doi: 10.1128/CVI.00026-15.

25. Hillerdal H, Henningsson AJ. Serodiagnosis of Lyme borreliosis-is IgM in serum more harmful than helpful? Eur J Clin Microbiol Infect Dis. 2021; 40(6):1161-1168. doi: 10.1007/s10096-020-04093-2.

26. Williams MT, Zhang Y, Pulse ME, et al. Suppression of host humoral immunity by Borrelia burgdorferi varies over the course of infection. Infect Immun. 2024; 92(4):e0001824. doi: 10.1128/iai.00018-24.

27. Hastey CJ, Olsen KJ, Elsner RA, et al. Borrelia burgdorferi infection-induced persistent IgM secretion controls bacteremia, but not bacterial dissemination or tissue burden. J Immunol. 2023; 211:1540–1549. doi: 10.4049/jimmunol.2300384.

28. Liang FT, Brown EL, Wang T, et al. Protective niche for Borrelia burgdorferi to evade humoral immunity. Am J Pathol. 2004. 165:977–985. doi: 10.1016/S0002-9440(10)63359-7.

29. Aguero-Rosenfeld ME, Nowakowski J, Bittker S, et al. Evolution of the serologic response to Borrelia burgdorferi in treated patients with culture-confirmed erythema migrans. J Clin Microbiol. 1996;34:1–9. doi: 10.1128/jcm.34.1.1-9.1996.

30. Kalish RA, McHugh G, Granquist J, et al. Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10- 20 years after active Lyme disease. Clin Infect Dis. 2001;33:780–785. doi: 10.1086/322669.


Review

For citations:


Baranova N.S., Ostapenko Y.S., Malysheva J.A., Malygina E.A., Kachura D.A., Zolotavkina S.S., Baranov A.A. Chronic neuroborreliosis and post-COVID syndrome: a clinical case. Patient-Oriented Medicine and Pharmacy. 2024;2(3):37-49. (In Russ.) https://doi.org/10.37489/2949-1924-0057. EDN: FOSOJL

Views: 354


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2949-1924 (Online)

Адрес редакции и издательства:

ООО «Издательство ОКИ»
115522, Москва, Москворечье ул., 4-5-129

Генеральный директор Афанасьева Елена Владимировна

Тел. + 7 (916) 986-04-65; Email: eva88@list.ru